AIDS : Pandemic of progressive immunodeficiency ...">
AIDS: Pandemic of progressive immunodeficiency
AIDSis caused by virus infection (HIV-1 and HIV-2)
Transmission principally via blood, heterosexual and homosexual sex and mother-to-child
Often co-infection with tuberculosis
Some treatable opportunistic infections (cost price): toxoplasmosis, PCP, candidiasis
Significance of prevention: no curative treatment
Importance of perinatal medication to reduce mother-to-child transmission with AZT, nevirapine or HAART
Importance of explanation, use of condoms, blood bank screening, STD control
HAART principle: combination therapy of different antiretrovirals
Aim of HAART: total viral suppression, avoidance of mutant selection, increase CD4 count
HAART: It is initially best to have two NRTIs + (one boosted PI or a potent NNRTI)
Rapid changing information: frequent updating essential
