Typhoid: important disease as regards frequency and mortality.
Salmonella typhi = Salmonella enteritidis serotype Typhi
Human reservoir, not a zoonosis
Fever, abdominal pain, diarrhoea/constipation, dry cough, splenomegaly, relative bradycardia, rarely roseola typhosa
Complications: ileal perforation, organ abscesses
Clinical diagnosis, leukopenia, faeces/urine/blood/bone marrow cultures
Widal test : serology has lack of specificity and sensitivity
Treatment quinolones, ceftriaxone (expensive), chloramphenicol, ampicillin, cotrimoxazole
Importance of relapse, antibiotic resistance, chronic carriers, gallstones, bilharzia.
